New lymphoma probes Zytolight
ZytoLight SPEC MALT1/IGH Dual Color Dual Fusion Probe (Prod. No. Z-2325-50).
The intended purpose of this probe is the qualitative detection of the translocation t(14;18)(q32.3;q21.3) involving the human MALT1 gene at 18q21.32 and the human IGH locus at 14q32.33 in formalin-fixed, paraffin-embedded specimens by FISH.
he MALT1/IGH fusion is a genetic rearrangement in which the MALT1 gene (which is involved in immune signaling) fuses with the IGH gene. This fusion results in the overexpression of MALT1. Detecting MALT1/IGH fusions is particularly useful in cancer diagnostics because the translocation t(14;18)/MALT1-IGH, along with the translocations t(11;18)/BIRC3-MALT1 and t(1;14)/BCL10-IGH, are specific to MALT lymphoma (a.k.a extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue). Thus, detecting this fusion can serve as a diagnostic biomarker for MALT lymphoma by helping pathologists differentiate it from other types of lymphoma or lymphoid tumors.
The intended purpose of this probe is the qualitative detection of the translocation t(14;18)(q32.3;q21.3) involving the human MALT1 gene at 18q21.32 and the human IGH locus at 14q32.33 in formalin-fixed, paraffin-embedded specimens by FISH.
he MALT1/IGH fusion is a genetic rearrangement in which the MALT1 gene (which is involved in immune signaling) fuses with the IGH gene. This fusion results in the overexpression of MALT1. Detecting MALT1/IGH fusions is particularly useful in cancer diagnostics because the translocation t(14;18)/MALT1-IGH, along with the translocations t(11;18)/BIRC3-MALT1 and t(1;14)/BCL10-IGH, are specific to MALT lymphoma (a.k.a extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue). Thus, detecting this fusion can serve as a diagnostic biomarker for MALT lymphoma by helping pathologists differentiate it from other types of lymphoma or lymphoid tumors.
ZytoLight SPEC TNFRSF14/1q25 Dual Color Probe (Prod. No. Z-2323-50).
The intended purpose of this probe is the qualitativedetection of human TNFRSF14 gene deletions and 1q25.3 specific sequences in formalin-fixed, paraffin-embedded specimens by fluorescence in situ hybridization (FISH).
Follicular lymphoma (FL) is a morphologically and genetically well-characterized B-cell non-Hodgkin lymphoma. Approximately 85% of FLs harbor the translocation t(14;18)(q32;q21), involving BCL2 and IGH, and consistently display a follicular growth pattern. However, some FL cases lack, partly or completely, this follicular organization. The hallmark translocation of FL, the t(14;18)(q32;q21), is absent in the large majority of these diffuse FL cases. Instead, most diffuse FL cases harbor a deletion in the 1p36 locus, in which the TNFRSF14 gene is located. FL with 1p36 deletion shows distinctive clinical, morphological and molecular features that distinguish it from classical FL.
The intended purpose of this probe is the qualitativedetection of human TNFRSF14 gene deletions and 1q25.3 specific sequences in formalin-fixed, paraffin-embedded specimens by fluorescence in situ hybridization (FISH).
Follicular lymphoma (FL) is a morphologically and genetically well-characterized B-cell non-Hodgkin lymphoma. Approximately 85% of FLs harbor the translocation t(14;18)(q32;q21), involving BCL2 and IGH, and consistently display a follicular growth pattern. However, some FL cases lack, partly or completely, this follicular organization. The hallmark translocation of FL, the t(14;18)(q32;q21), is absent in the large majority of these diffuse FL cases. Instead, most diffuse FL cases harbor a deletion in the 1p36 locus, in which the TNFRSF14 gene is located. FL with 1p36 deletion shows distinctive clinical, morphological and molecular features that distinguish it from classical FL.
