New probe ZytoLight SPEC IGL Dual Color Break Apart Probe (Prod. No. Z-2286-50)

The ZytoLight SPEC IGL Dual Color Break Apart Probe (Prod. No. Z-2286-50) is designed to detect rearrangements affecting the chromosomal region 22q11.22 harboring the IGL (immunoglobulin lambda locus, a.k.a. IGL@) gene cluster region. Burkitt’s lymphoma (BL) are characterized by reciprocal translocations involving the MYC gene and one of the IG loci. The majority of translocations involve the immunoglobulin heavy chain (IGH) locus while a minor part involves the immunoglobulin light chain loci, either the kappa light chain (IGK) or the lambda light chain (IGL). IGK and IGL rearrangements resulting from the variant translocations t(2;8)(p12;q24.21) and t(8;22)(q24.21;q11.2), respectively, have been detected in up to 25% of BL cases. In non-Hodgkin Lymphoma (NHL) harboring IG-MYC rearrangements, the MYC translocation partner is IGK and IGL in 8 and 22% of the cases. IG translocations have been reported in several B-cell lineage malignancies other than BL including atypical Burkitt/Burkitt-like lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and multiple myeloma.