ZytoLight SPEC IKZF1/CEN 7 Dual Color Probe (Prod. No. Z-2304-50)

The ZytoLight SPEC IKZF1/CEN 7 Dual Color Probe (Prod. No. Z-2304-50) is designed

for the detection of deletions affecting the IKZF1 gene. The IKZF1 gene is located on 7p12.2

and encodes a zinc finger transcription factor, which is required for normal hematopoietic

differentiation and proliferation, particularly in lymphoid lineages.

Genomic deletions affecting the IKZF1 gene are found in approximately 15% of pediatric

and ~40% of adult B-cell precursor acute lymphoblastic leukemia (B-ALL) cases. The

frequency is remarkably high in BCR-ABL1-positive (~70%) and BCR-ABL1-like (~40%)

pediatric B-ALL. The most frequent deletions in B-ALL affect the whole gene or exons 4 to

7.

 

IKZF1 deletions are associated with poor prognosis and high risk of relapse in cases of B￾

ALL. Hence, the detection of IKZF1 deletions by FISH may help in predicting the clinical

outcome in patients with B-ALL.

 

 

For more information and pricing please contact: info@pragostem.cz