New FISH probes Zytolight
NEW FISH probe related to hematology:
The ZytoLight SPEC TCF3/PBX1 Dual Color Dual Fusion Probe (Prod. No. Z-2308-50) is designed to detect rearrangements affecting the chromosomal region 19p13.3 harboring the TCF3 (a.k.a. E2A) gene and the chromosomal region 1q23.3 harboring the PBX1 gene. TCF3 is the target of several known recurrent rearrangements in ALL that create TCF3 fusion proteins.
NEW FISH probes related to microdeletion syndromes:
The ZytoLight SPEC Prader-Willi Dual Color Probe (Prod. No. Z-2318-50) is designed to detect deletions affecting the chromosomal region 15q11.2 harboring the SNRPN gene. The Prader-Willi syndrome (PWS) is a sporadic genetic disorder caused by genomic errors that inactivate paternally-inherited genes in the PWS critical region on chromosome 15q11-q13. The absence of expression of one or more of these genes contributes to different phenotypes of PWS.
The ZytoLight SPEC Angelman Dual Color Probe (Prod. No. Z-2319-50) is intended to be used for the qualitative detection of human UBE3A gene deletions as well as the detection of the human PML gene in cytologic specimens by fluorescence in situ hybridization (FISH).
NEW FISH probe related to lung cancer and lymphoma:
The ZytoLight SPEC TP63/TBL1XR1 TriCheckTM Probe (Prod. No. Z-2320-50) is intended to be used for the qualitative detection of rearrangements involving the human TP63 gene at 3q28 and the human TBL1XR1 gene at 3q26.32 in formalin-fixed, paraffin-embedded specimens by fluorescence in situ hybridization (FISH).
NEW FISH probe related to sarcomas and hematology:
The ZytoLight SPEC RB1/13q34 Dual Color Probe (Prod. No. Z-2324-50/-200) is designed for the detection of deletions affecting the RB1 gene. Deletions of RB1 are frequently found in retinoblastoma. However, either monoallelic or biallelic deletions of RB1 are also common in a wide variety of solid tumors and hematologic malignancies such as multiple myeloma (MM) and chronic lymphocytic leukemia (CLL).
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