ZytoLight SPEC IKZF1/CEN 7 Dual Color Probe (Prod. No. Z-2304-50)
The ZytoLight SPEC IKZF1/CEN 7 Dual Color Probe (Prod. No. Z-2304-50) is designed
for the detection of deletions affecting the IKZF1 gene. The IKZF1 gene is located on 7p12.2
and encodes a zinc finger transcription factor, which is required for normal hematopoietic
differentiation and proliferation, particularly in lymphoid lineages.
Genomic deletions affecting the IKZF1 gene are found in approximately 15% of pediatric
and ~40% of adult B-cell precursor acute lymphoblastic leukemia (B-ALL) cases. The
frequency is remarkably high in BCR-ABL1-positive (~70%) and BCR-ABL1-like (~40%)
pediatric B-ALL. The most frequent deletions in B-ALL affect the whole gene or exons 4 to
IKZF1 deletions are associated with poor prognosis and high risk of relapse in cases of B
ALL. Hence, the detection of IKZF1 deletions by FISH may help in predicting the clinical
outcome in patients with B-ALL.
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